DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination.
نویسنده
چکیده
The repair of DNA double-strand breaks by homologous recombination commences by nucleolytic degradation of the 5'-terminated strand of the DNA break. This leads to the formation of 3'-tailed DNA, which serves as a substrate for the strand exchange protein Rad51. The nucleoprotein filament then invades homologous DNA to drive template-directed repair. In this review, I discuss mainly the mechanisms of DNA end resection in Saccharomyces cerevisiae, which includes short-range resection by Mre11-Rad50-Xrs2 and Sae2, as well as processive long-range resection by Sgs1-Dna2 or Exo1 pathways. Resection mechanisms are highly conserved between yeast and humans, and analogous machineries are found in prokaryotes as well.
منابع مشابه
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 290 38 شماره
صفحات -
تاریخ انتشار 2015